Nowdays, investors need to be selective to invest in mutual fund. In general, to know the mutual fund's performance, investors can use the Net Assets Value (NAV). Many factors were considered to affect the value of net assets in mutual funds. In this research, we used the mixed mutual fundsconsisted of fifteen members as samples. The research used time series multiple regression method. The specific goal of this research is to know the influence of macro economic factors (interest rate of Bank Indonesia, exchange rate of US Dollar and Indonesia Stock Exchange Index) to the mixed mutual fund performance in Indonesia from 2006 until 2010. The result of this research proved that together the interest rate of Bank Indonesia, the exchange rate of US Dollar and the Indonesian Stock Exchange Index had significant influence to the mixed mutual fund performance from 2006 until 2010. Partially, only Indonesian Stock Exchange Index had significant effect to the mixed mutual fund performance from 2006 until 2010.