One of the important decisions faced by financial managers in relation to continuity of operations the company is financing decisions or capital structure decision, because it relates to many stakeholders such as creditors, shareholders, and management company itself. A firm has a particular funding structure in carrying out financial functions of which one can proxy for leverage, the ratio between liabilities with total assets owned. This study is to know and test the effect of the return on assets, the dividend payout ratio, the fixed assets ratio, and the exchange rate to capital structure of the issuer's LQ 45 at the Indonesia Stock Exchange in the period 2005 to 2009 that analyzed using the multiple regressions. Based on these results, the return on assets and the currency factor have significant effects to the capital structure.